Chemical Substance - Poloxamer 407. NHPID name: Poloxamer 407. Reference: ICID Proper name(s): Poloxamer 407 Common name(s): Poloxamer 407 Category: Approved Chemical Name. Roles. Non-medicinal. Purposes: Binder.. Poloxamer 407 formulations led to enhanced solubilisation of poorly water-soluble drugs and prolonged release profile for many galenic applications (e.g., oral, rectal, topical, ophthalmic, nasal and injectable preparations) but did not clearly show any relevant advantages when used alone. Combination with other excipients like Poloxamer 188 or.

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The viscosity curve of Poloxamer 407. Download Scientific Diagram

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B Kolliphor® P 407 Poloxamer 407 Gelling agent 15 - 20 Deionized Water Solvent 53 - 58 Gelling is a function of temperature, structure, and concentration of a given poloxamer. At high enough concentrations, poloxamers form multimolecular aggregates and micelles that aid in gelling. Notably, an increase in the amount of ethanol used in a. Poloxamer 407, also known by the trademark Pluronic® F127, is a water-soluble, non-ionic triblock copolymer that is made up of a hydrophobic residue of polyoxypropylene (POP) between the two hydrophilic units of polyoxyethylene (POE).. These tests serve as a comparative tool during the development of topical formulations. Drug release into.